4.5 Article

Pinosylvin inhibits migration and invasion of nasopharyngeal carcinoma cancer cells via regulation of epithelial-mesenchymal transition and inhibition of MMP-2

Journal

ONCOLOGY REPORTS
Volume 46, Issue 1, Pages -

Publisher

SPANDIDOS PUBL LTD
DOI: 10.3892/or.2021.8094

Keywords

pinosylvin; nasopharyngeal cancer; matrix metalloproteinase; epithelial-mesenchymal transition; MAPK

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Funding

  1. Changhua Christian Hospital [109-CCH-IRP-013]

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The study demonstrated that pinosylvin inhibited migration and invasion in nasopharyngeal carcinoma cells, potentially through modulation of multiple signaling pathways.
Nasopharyngeal carcinoma (NPC) is a tumor located in the nasopharynx with highly invasive and metastatic properties. Metastasis is a primary cause of mortality in patients with NPC. The terpenoid polyphenol pinosylvin is a known functional compound of the Pinus species that exhibits anti-inflammatory effects; however, the effect of pinosylvin on human NPC cell migration and invasion is unclear. The present study aimed to investigate the functional role of pinosylvin in NPC cells (NPC-039, NPC-BM and RPMI 2650). Gap closure and Transwell assay indicated that pinosylvin at increasing concentrations inhibited migration and invasion of NPC-039 and NPC-BM cells. In addition to inhibiting the enzyme activity of MMP-2, pinosylvin also decreased the protein expression levels of MMP-2 and MMP-9. Pinosylvin decreased the expression of vimentin and N-cadherin and significantly increased the expression of zonula occludens-1 and E-cadherin in NPC cells. Additionally, pinosylvin suppressed the invasion and migration ability of NPC-039 and NPC-BM cells by mediating the p38, ERK1/2 and JNK1/2 pathways. The present results revealed that pinosylvin inhibited migration and invasion in NPC cells.

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