Journal
OBESITY SURGERY
Volume 31, Issue 12, Pages 5224-5236Publisher
SPRINGER
DOI: 10.1007/s11695-021-05702-5
Keywords
Severe obesity; Inflammation; Adipokines; Weight loss
Categories
Funding
- Coordenacao de Apoio ao Pessoal de Nivel Superior (CAPES/PROSUP)
- Fundacao de Amparo a Pesquisa (FAPEG), Goias (GO), Brazil
- Research Productivity, modality PQ1D
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil [312731/2018-3]
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This study confirmed the effectiveness of weight loss induced by surgery in improving lipid profile and reducing chronic inflammatory status in severely obese women. The analysis of various indicators pre- and post-surgery showed significant changes, particularly in resistin, IGF-1, and IL-23 levels.
Introduction/Purpose Obesity increases significantly every year worldwide. Since 1980, the prevalence of individuals with obesity has practically doubled. Obesity plays an important role in the pathophysiology of diseases that arise from a complex interaction of nutritional, genetic, and metabolic factors, characterizing a chronic inflammatory state. This study aimed to verify the systemic inflammatory response through the analysis of IGF-1, IL-23, and resistin levels and the lipid profile in severely obese women undergoing surgery for obesity and weight-related diseases. Materials and Methods This randomized controlled clinical trial includes female patients clinically diagnosed with severe obesity with an indication for bariatric surgery. Results In the initial evaluation, no significant difference was observed between the control (CG) and bariatric surgery (BSG) groups. The weight, BMI, systolic and diastolic blood pressures, total cholesterol, LDL, HDL, total non-HDL cholesterol, and glucose in BSG patients showed a significant change after surgery. Pre- and post-surgery levels of resistin, IGF-1, and IL-23 showed a significant difference in the BSG group, but only IL-23 was changed after 6 months in the CG. Conclusion The results of this study confirmed that weight loss induced by surgery for obesity and weight-related diseases improved the lipid profile and reduced the chronic inflammatory status in women with severe obesity.
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