Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 40, Issue 7, Pages 707-719Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2021.1929317
Keywords
Interleukin-1; polymorphism; lymphoma
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Funding
- Zahedan University of Medical Sciences [8999]
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The study investigated the impact of IL-1A, IL-1B, and IL-1R1 polymorphisms on lymphoma, and found that certain genotypes were associated with increased or decreased risks for different types of lymphoma.
We investigate the impact of IL-1A, IL-1B and IL-1R1 polymorphism on lymphoma. This study consisted of 155 Non-Hodgkin's lymphoma (NHL) patients 55 Hodgkin's lymphoma (HL) patients and 150 healthy individuals. PCR-RFLP method and ARMS PCR were used for genotyping of IL-1A rs3783553, IL-1B rs3917356, rs16944, IL-1R1 rs10490571 and IL-1A rs3783550 polymorphism. The results showed that the CC genotype of rs3783550 as well Ins/del of rs3783553 increased the risk of NHL. In contrast the AG genotype of rs3917356 and AG also AG + AA genotype of rs10490571 decreased the risk of NHL. The result revealed that the CC genotype of rs3783550 and AG genotype of rs3917356 increased risk of HL.
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