Journal
NMR IN BIOMEDICINE
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/nbm.4616
Keywords
brain; distortion; magnetic resonance elastography; off-resonance; viscoelasticity
Funding
- National Institutes of Health [F31-HD103361, R01-AG058853, R01-EB027577, U01-NS112120]
- Delaware INBRE Program [P20-GM103446]
- University of Delaware Research Foundation
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Off-resonance related geometric distortion can impact quantitative MRI techniques like MRE, affecting the estimated mechanical properties. Different k-space trajectories and correction methods can influence the accuracy of the measurements, with traditional distortion correction pipelines being effective in reducing stiffness errors, but with limitations in cases of very large distortion.
Off-resonance related geometric distortion can impact quantitative MRI techniques, such as magnetic resonance elastography (MRE), and result in errors to these otherwise sensitive metrics of brain health. MRE is a phase contrast technique to determine the mechanical properties of tissue by imaging shear wave displacements and estimating tissue stiffness through inverse solution of Navier's equation. In this study, we systematically examined the quantitative effects of distortion and corresponding correction approaches on MRE measurements through a series of simulations, phantom models, and in vivo brain experiments. We studied two different k-space trajectories, echo-planar imaging and spiral, and we determined that readout time, off-resonance gradient strength, and the combination of readout direction and off-resonance gradient direction, impact the estimated mechanical properties. Images were also processed through traditional distortion correction pipelines, and we found that each of the correction mechanisms works well for reducing stiffness errors, but are limited in cases of very large distortion. The ability of MRE to detect subtle changes to neural tissue health relies on accurate, artifact-free imaging, and thus off-resonance related geometric distortion must be considered when designing sequences and protocols by limiting readout time and applying correction where appropriate.
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