Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

Article Immunology

Impact of the Coronavirus Disease 2019 (COVID-19) Vaccine on Asymptomatic Infection Among Patients Undergoing Preprocedural COVID-19 Molecular Screening

Aaron J. Tande et al.

Summary: This study found a significant association between vaccination with mRNA-based COVID-19 vaccines and reduced risk of asymptomatic SARS-CoV-2 infection.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Immunology

The Importance of Advancing Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Children

Carol M. Kao et al.

Summary: Despite the unclear role of children in SARS-CoV-2 transmission, they are likely to play an important role based on our knowledge of other respiratory viruses. Due to children being more likely to be asymptomatic or have mild symptoms, current estimates of SARS-CoV-2 burden in children may be underestimated.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Pediatrics

Risk Factors for Severity in Children with Coronavirus Disease 2019 A Comprehensive Literature Review

Sophia Tsabouri et al.

PEDIATRIC CLINICS OF NORTH AMERICA (2021)

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Editorial Material Immunology

Schools Closures During the COVID-19 Pandemic A Catastrophic Global Situation

Danilo Buonsenso et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2021)

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Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Pediatrics

SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges

Dan M. Cooper et al.

Summary: There are key challenges to address in implementing pediatric SARS-CoV-2 vaccines, including understanding the impact of immune system maturation on vaccine effectiveness, the rationale for vaccines in children, ethical concerns, specific needs of children with developmental disorders and chronic conditions, health inequities, and vaccine hesitancy. Careful consideration of the risk-benefit of a pediatric SARS-CoV-2 vaccine is necessary due to the milder symptoms of COVID-19 in children. Efforts must also be made to address health equity issues and general vaccine hesitancy in pediatric populations.

PEDIATRIC RESEARCH (2021)

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Article Multidisciplinary Sciences

Prevalence of COVID-19 in adolescents and youth compared with older adults in states experiencing surges

Barbara Rumain et al.

Summary: Research showed that prevalence of COVID-19 was significantly higher in adolescents and youth compared to older adults, contradicting previous findings. The percentage of cases observed divided by expected was also higher in adolescents and youth, with deviation being greater when observed cases exceeded expectations and less when observed cases were fewer than expected.

PLOS ONE (2021)

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Review Environmental Sciences

Impact of COVID-19 on Mental Health in Adolescents: A Systematic Review

Elizabeth A. K. Jones et al.

Summary: Adolescents globally, from different backgrounds, experience higher rates of anxiety, depression, and stress during the COVID-19 pandemic, along with higher frequency of alcohol and cannabis use. Positive social support, coping skills, and family discussions seem to have a positive impact on adolescent mental health during this crisis.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Public, Environmental & Occupational Health