Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 384, Issue 21, Pages 2039-2052Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMra2101920
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DNA mutations occur in nearly every tissue throughout human life. If a mutated clone gains competitive advantage, clonal dominance may emerge, leading to functional consequences and disease.
Somatic Mutations in Benign Disease DNA mutations occur in nearly every tissue throughout the human life span and accumulate at various rates in different tissues according to intrinsic and extrinsic factors. If a mutated clone acquires features that confer a competitive advantage, clonal dominance can emerge. Such alterations can have functional consequences and cause disease.
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