SARS-CoV-2 Human Challenge Studies - Establishing the Model during an Evolving Pandemic

Article Immunology

Viewpoint of a WHO Advisory Group Tasked to Consider Establishing a Closely-monitored Challenge Model of Coronavirus Disease 2019 (COVID-19) in Healthy Volunteers

Myron M. Levine et al.

Summary: The World Health Organization formed an Advisory Group to discuss the feasibility, potential value, and limitations of establishing a closely-monitored challenge model of SARS-CoV-2 infection and COVID-19 in healthy adult volunteers. The report highlights the challenges in setting up a COVID-19 model and suggests prudent strategies for model development, challenge virus selection, and containment measures. While a COVID-19 model may demonstrate protection against illness induced by prior SARS-CoV-2 challenge or vaccination, its limitations include the inability to directly predict vaccine efficacy in elderly or high-risk adults based on experiments with young healthy adults.

CLINICAL INFECTIOUS DISEASES (2021)

Add to Collection

Article Immunology

Assessment of Risks Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Experimental Human Infection Studies

Vincent P. Kuiper et al.

Summary: Controlled human infection models for SARS-CoV-2 have been proposed to expedite the development of vaccines and drugs, but come with inherent risks that must be carefully evaluated and mitigated to minimize negative impacts on participants and the community.

CLINICAL INFECTIOUS DISEASES (2021)

Add to Collection

Article Immunology

Key criteria for the ethical acceptability of COVID-19 human challenge studies: Report of a WHO Working Group

Euzebiusz Jamrozik et al.

Summary: This report from the WHO outlines ethical standards for COVID-19 challenge studies, including eight Key Criteria related to scientific justification, risk-benefit assessment, consultation and engagement, etc. It provides comprehensive guidance to ensure that such studies meet ethical requirements.

VACCINE (2021)

Add to Collection

Article Immunology

Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure

Nir Eyal et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

Add to Collection

Article Medicine, General & Internal

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study

Ash K. Clift et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Add to Collection

SARS-CoV-2 Human Challenge Studies - Establishing the Model during an Evolving Pandemic

Related references

Viewpoint of a WHO Advisory Group Tasked to Consider Establishing a Closely-monitored Challenge Model of Coronavirus Disease 2019 (COVID-19) in Healthy Volunteers

Assessment of Risks Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Experimental Human Infection Studies

Key criteria for the ethical acceptability of COVID-19 human challenge studies: Report of a WHO Working Group

Human Challenge Studies to Accelerate Coronavirus Vaccine Licensure

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study

Export Citation

Share Paper