Journal
NEUROTOXICOLOGY AND TERATOLOGY
Volume 87, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ntt.2021.106984
Keywords
GLP-1; Development; Brain; Pregnancy; Anxiety; Developmental programming
Categories
Funding
- NIH [R03 MH110749]
- FSU Council on Research Creativity
- FSU College of Medicine
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The use of GLP-1R agonists during pregnancy has some effects on both dams and offspring, with the offspring primarily showing differences in weight and anxiety-like behaviors, which may be sex-specific.
Evidence supporting the use of glucagon-like peptide-1 (GLP-1) analogues to pharmacologically treat disorders beyond type 2 diabetes and obesity is increasing. However, little is known about how activation of the GLP-1 receptor (GLP-1R) during pregnancy affects maternal and offspring outcomes. We treated female C57Bl/6 J mice prior to conception and throughout gestation with a long-lasting GLP-1R agonist, Exendin-4. While GLP-1R activation has significant effects on food and drug reward, depression, locomotor activity, and cognition in adults, we found few changes in these domains in exendin-4-exposed offspring. Repeated injections of Exendin-4 had minimal effects on the dams and may have enhanced maternal care. Offspring exposed to the drug weighed significantly more than their control counterparts during the preweaning period and demonstrated alterations in anxiety-like outcomes, which indicate a developmental role for GLP-1R modulation in the stress response that may be sex-specific.
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