Journal
NEUROTOXICITY RESEARCH
Volume 39, Issue 6, Pages 2175-2185Publisher
SPRINGER
DOI: 10.1007/s12640-021-00408-z
Keywords
Neuroinflammation; Gut microbiota; Alzheimer's disease; GPR40
Categories
Funding
- Research and Development Fund Project of Kangda College, Nanjing Medical University [KD2019KYJJZD018]
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This study highlights the importance of the relationship between gut microbiota and immune system disorder in the neuropathology of Alzheimer's disease, providing a new direction for the treatment of AD by focusing on the advanced mechanism of inflammatory response.
Alzheimer's disease (AD) is a central disease with high incidence, and its pathological process is closely associated with changes of some biological indicators in the periphery. Among them, the intestinal flora mainly causes a series of pathological changes such as inflammation through the immune system, which may contribute to the pathological process of AD. In this paper, we mainly focused the relationship between gut microbiota and immune system disorder in the neuropathology of AD, underlining the significance of the advanced mechanism of inflammatory response and providing a new direction for the treatment of AD.
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