Journal
NEUROSCIENCE LETTERS
Volume 762, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2021.136166
Keywords
Parkinson's disease; Autophagy; Circadian rhythm
Categories
Funding
- National Natural Science Foundation of China [81801253]
- Natural Science Foundation of Jiangsu Province [BK20180214, GSWS2020118]
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Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting dopaminergic neurons. Abnormal autophagy and circadian dysfunction are two characteristics of PD. Blood sample analysis revealed decreased levels of BECN1 and LAMP2 in PD patients, suggesting a potential manifestation of abnormal biological rhythm in PD.
Parkinson's disease (PD) is the second most common neurodegenerative disorder and affects dopaminergic neurons. Autophagy often shows a circadian rhythm pattern under physiological conditions across 24 h. Abnormal autophagy and circadian dysfunction are two characteristics of PD. Whether the rhythm of autophagy is altered in PD has not yet been reported. Therefore, in this study, we collected peripheral blood samples at 6:00 h and 18:00 h from PD patients and age-matched controls, and analyzed the mRNA expressions of ULK1, BECN1, LAMP2, AMPK, and SNCA using real-time quantitative PCR. Blood samples analysis found that BECN1 and LAMP2 levels were decreased in patients with PD. Simultaneously, the rhythm of autophagy in PD is not consistent with that in the Control group, which may be a manifestation of the abnormal biological rhythm of PD.
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