Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 128, Issue -, Pages 367-382Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.06.030
Keywords
Lewy body disease; Visual hallucinations; Dementia with Lewy bodies; Meta-analysis; VBM; MRI; Grey matter volume; Neuropsychology; Memory; Parkinson's disease
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Funding
- University of Sheffield
- Erasmus+program of the European Union
- Instituto de Salud Carlos III
- European Union (ERDF/ESF, 'Investing in your future') [CPII19/00009, PI19/00394]
- National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre (BRC) based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University
- PERIS (Generalitat de Catalunya) [SLT008/18/00088]
- Rio Hortega, Instituto de Salud Carlos III (ISCIII), Spain [CM17/00209]
- FIS grant, Instituto de Salud Carlos III (ISCIII), Spain [PI18/01717]
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The study found that visual hallucinations in patients with Parkinson's disease and dementia with Lewy bodies are associated with reductions in grey matter volume in certain brain regions, as well as lower verbal immediate memory performance in Parkinson's disease patients.
Visual hallucinations (VH) are common in Parkinson's disease and dementia with Lewy bodies, two forms of Lewy body disease (LBD), but the neural substrates and mechanisms involved are still unclear. We conducted meta-analyses of voxel-based morphometry (VBM) and neuropsychological studies investigating the neuroanatomical and cognitive correlates of VH in LBD. For VBM (12 studies), we used Seed-based d Mapping with Permutation of Subject Images (SDM-PSI), including statistical parametric maps for 50% of the studies. For neuropsychology (35 studies), we used MetaNSUE to consider non-statistically significant unreported effects. VH were associated with smaller grey matter volume in occipital, frontal, occipitotemporal, and parietal areas (peak Hedges' g-0.34 to-0.49). In patients with Parkinson's disease without dementia, VH were associated with lower verbal immediate memory performance (Hedges' g-0.52). Both results survived correction for multiple comparisons. Abnormalities in these brain regions might reflect dysfunctions in brain networks sustaining visuoperceptive, attention, and executive abilities, with the latter also being at the basis of poor immediate memory performance.
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