Routes of the thalamus through the history of neuroanatomy

The most distant roots of neuroanatomy trace back to antiquity, with the first human dissections, but no document which would identify the thalamus as a brain structure has reached us. Claudius Galenus (Galen) gave to the thalamus the name ?thalamus nervorum opticorum?, but later on, other names were used (e.g., anchae, or buttocks-like). In 1543, Andreas Vesalius provided the first quality illustrations of the thalamus. During the 19th century, tissue staining techniques and ablative studies contributed to the breakdown of the thalamus into subregions and nuclei. The next step was taken using radiomarkers to identify connections in the absence of lesions. Anterograde and retrograde tracing methods arose in the late 1960s, supporting extension, revision, or confirmation of previously established knowledge. The use of the first viral tracers introduced a new methodological breakthrough in the mid-1970s. Another important step was supported by advances in neuroimaging of the thalamus in the 21th century. The current review follows the history of the thalamus through these technical revolutions from Antiquity to the present day.

Automated summary

The history of neuroanatomy dates back to antiquity with human dissections, and over the years, various methods such as tissue staining, ablative studies, radiomarkers, and viral tracers have been used to identify and understand the structure and connections of the thalamus. Technological breakthroughs have allowed for a deeper insight into the functions of the thalamus from ancient times to the present day.