Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 125, Issue -, Pages 110-121Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2021.02.024
Keywords
Neurodevelopmental disorders; Olfaction; Sensory circuits; Mouse models of neurological disease; Anosmia; Hyposmia
Categories
Funding
- BRASS: Baylor Research Advocates for Student Scientists
- AHA [20PRE35040011]
- DOD [PR180451PRMP]
- NIDDK [R01DK109934]
- NINDS [4R01NS078294, U01NS111692, 1K12NS098482]
- Neuroconnectivity Core at Baylor College of Medicine - IDDRC from the Eunice Kennedy Shriver National Institute of Child Health & Human Development [1 U54 HD083092]
- McNair Medical Institute
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This systematic literature review of olfactory function testing in mouse models of neurodevelopmental disorders identified intriguing inconsistencies, including evidence for both increased and decreased acuity in odor detection in various mouse models of Autism Spectrum Disorder (ASD). The authors recommend direct comparison of different mouse models of ASD using standardized tests for odor detection and discrimination to guide future research in this area.
Olfactory impairment is a common clinical motif across neurodevelopmental disorders, suggesting olfactory circuits are particularly vulnerable to disease processes and can provide insight into underlying disease mechanisms. The mouse olfactory bulb is an ideal model system to study mechanisms of neurodevelopmental disease due to its anatomical accessibility, behavioral relevance, ease of measuring circuit input and output, and the feature of adult neurogenesis. Despite the clinical relevance and experimental benefits, olfactory testing across animal models of neurodevelopmental disease has been inconsistent and non-standardized. Here we performed a systematic literature review of olfactory function testing in mouse models of neurodevelopmental disorders, and identified intriguing inconsistencies that include evidence for both increased and decreased acuity in odor detection in various mouse models of Autism Spectrum Disorder (ASD). Based on our identified gaps in the literature, we recommend direct comparison of different mouse models of ASD using standardized tests for odor detection and discrimination. This review provides a framework to guide future olfactory function testing in mouse models of neurodevelopmental diseases.
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