Journal
NEURORADIOLOGY
Volume 64, Issue 2, Pages 279-288Publisher
SPRINGER
DOI: 10.1007/s00234-021-02767-y
Keywords
Entorhinal cortex; Mini-Mental State Examination; MRI; ADNI
Funding
- Clinical Research Promotion Foundation
Ask authors/readers for more resources
This study aimed to discover common biomarkers correlating with the Mini-Mental State Examination (MMSE) scores from multi-country MRI datasets. A positive correlation was identified between right entorhinal cortex (ERC) thickness and MMSE score, indicating a potential biomarker for cognitive function assessment.
Purpose To discover common biomarkers correlating with the Mini-Mental State Examination (MMSE) scores from multi-country MRI datasets. Methods The first dataset comprised 112 subjects (49 men, 63 women; range, 46-94 years) at the National Hospital Organization Kyushu Medical Center. A second dataset comprised 300 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (177 men, 123 women; range, 57-91 years). Three-dimensional T1-weighted MR images were collected from both datasets. In total, 14 deep gray matter volumes and 70 cortical thicknesses were obtained from MR images using FreeSurfer software. Total hippocampal volume and the ratio of hippocampus to cerebral volume were also calculated. Correlations between each variable and MMSE scores were assessed using Pearson's correlation coefficient. Parameters with moderate correlation coefficients (r > 0.3) from each dataset were determined as independent variables and evaluated using general linear model (GLM) analyses. Results In Pearson's correlation coefficient, total and bilateral hippocampal volumes, right amygdala volume, and right entorhinal cortex (ERC) thickness showed moderate correlation coefficients (r > 0.3) with MMSE scores from the first dataset. The ADNI dataset showed moderate correlations with MMSE scores in more variables, including bilateral ERC thickness and hippocampal volume. GLM analysis revealed that right ERC thickness correlated significantly with MMSE score in both datasets. Cortical thicknesses of the left parahippocampal gyrus, left inferior parietal lobe, and right fusiform gyrus also significantly correlated with MMSE score in the ADNI dataset (p < 0.05). Conclusion A positive correlation between right ERC thickness and MMSE score was identified from multi-country datasets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available