Journal
NEURON
Volume 109, Issue 16, Pages 2503-2505Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2021.07.023
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The study found that early Tlr4-dependent inflammation permanently alters neuronal function in microglia, making male mice more susceptible to stress-induced depressive-like behaviors later in life.
Inflammation during critical windows of development contributes to behavioral affect later in life. In this of Neuron, Cao et al. (2021) demonstrate a novel mechanism through which early life Tlr4-dependent inflammation in microglia permanently alters neuronal function and leaves male mice susceptible to stress-induced depressive-like behaviors.
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