Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 147, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2021.105017
Keywords
Blood-brain barrier; Liposome; Nanoparticle; Receptor
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The blood-brain barrier presents challenges in drug delivery to the central nervous system, but surface modified nanocarrier systems are being explored as a potential solution. Liposomes and solid nanoparticles are the main systems being tested currently.
The blood-brain barrier represents the major challenge for delivering drugs to the central nervous system (CNS). It separates the blood circulation from the brain tissue, thereby protecting the CNS and maintaining its ion homeostasis. Unfortunately, most drugs are not able to cross this barrier in vivo despite promising in vitro results. One approach to solve this problem is the delivery of drugs via surface modified nanocarrier systems. This review will give an overview on currently tested systems, mainly liposomes and solid nanoparticles and inform about new developments.
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