Journal
NEUROBIOLOGY OF AGING
Volume 108, Issue -, Pages 168-178Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2021.09.004
Keywords
Alzheimer's disease; Primary progressive aphasia; Dementia; Episodic memory; Parietal
Categories
Funding
- National Health and Medical Research Council (NHMRC) of Australia [APP1037746]
- Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders Memory Program [CE110001021]
- Faculty of Science PhD. Research Scholarship from The University of Sydney
- NHMRC [APP1103258]
- ARC [FT160100096, DP180101548]
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Episodic amnesia has been found as a potential clinical feature in Logopenic Progressive Aphasia (LPA) patients, even persisting when structured probing is provided. Autobiographical memory impairments in LPA are related to gray matter intensity decrease in predominantly posterior parietal brain regions implicated in memory retrieval.
Although characterized primarily as a language disorder, mounting evidence indicates episodic amnesia in Logopenic Progressive Aphasia (LPA). Whether such memory disturbances extend to information encoded pre-disease onset remains unclear. To address this question, we examined autobiographical memory in 10 LPA patients, contrasted with 18 typical amnestic Alzheimer's disease and 16 healthy Control participants. A validated assessment, the Autobiographical Interview, was employed to explore autobiographical memory performance across the lifespan under free and probed recall conditions. Relative to Controls, LPA patients showed global impairments across all time periods for free recall, scoring at the same level as disease-matched cases of Alzheimer's disease. Importantly, these retrieval deficits persisted in LPA, even when structured probing was provided, and could not be explained by overall level of language disruption or amount of information generated during autobiographical narration. Autobiographical memory impairments in LPA related to gray matter intensity decrease in predominantly posterior parietal brain regions implicated in memory retrieval. Together, our results suggest that episodic memory disturbances may be an under-appreciated clinical feature of LPA. (c) 2021 Elsevier Inc. All rights reserved.
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