Journal
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Volume 394, Issue 10, Pages 1991-2002Publisher
SPRINGER
DOI: 10.1007/s00210-021-02131-0
Keywords
Metal nanoparticles; Metal oxide nanoparticles; Osteoarthritis; Cartilage; Oxidative stress
Categories
Funding
- Medical Health Science and Technology Project of Zhejiang Provincial Health Commission [NSAP-D-21-00222R1, 2021KY028]
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Nanoparticles show potential benefits in treating osteoarthritis by simulating antioxidant enzyme activity and catalyzing the degradation of superoxide anions, thus alleviating inflammation and promoting cartilage repair.
The current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.
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