Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 28, Issue 7, Pages 543-545Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41594-021-00608-3
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Funding
- NIH [R01GM112846, R01NS121114, R01GM120625, R01NS108376]
- St. Jude Children's Research Hospital Research Collaborative on Membrane-less Organelles in Health and Disease
- American Lebanese Syrian Associated Charities
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A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. The oncogenic properties of one such fusion, NUP98-HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated onco-condensates.
A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98-HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated onco-condensates.
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