Targeting calcium-related mechanotransduction in early OA

Sensation of mechanical stimuli by chondrocytes is critical to cartilage homeostasis and osteoarthritis development. The earliest responses in chondrocyte mechanotransduction pathways involve calcium influx and changes in mitochondrial function, which occur in seconds to minutes. Deeper understanding of these events can elucidate new therapeutic targets for early intervention to prevent osteoarthritis.

Automated summary

Mechanical stimuli sensation by chondrocytes is crucial for cartilage homeostasis and osteoarthritis development. The early responses in chondrocyte mechanotransduction pathways involve calcium influx and changes in mitochondrial function, which occur within seconds to minutes. Understanding these events can reveal new therapeutic targets for early intervention to prevent osteoarthritis.