Journal
NATURE REVIEWS NEUROSCIENCE
Volume 22, Issue 10, Pages 593-615Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41583-021-00496-y
Keywords
-
Categories
Funding
- US National Institutes of Health [R21NS114549, R01EB027666, R01EB027171]
- US National Science Foundation [DMR1808415, CBET2033302]
- National Science Foundation Future Manufacturing Program [2037164]
- National Science Foundation Graduate Research Fellowship Program [DGE-1656518]
- Stanford Smith Family Graduate Fellowship
- Stanford ChEM-H O'Leary-Thiry Graduate Fellowship
- Stanford Bio-X seed grant
- Stanford Brain Organogenesis Program in the Wu Tsai Neurosciences Institute
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [2037164] Funding Source: National Science Foundation
Ask authors/readers for more resources
Human pluripotent stem cell-derived in vitro models have the potential to study aspects of human brain development, but they currently have limitations in fully recapitulating certain features of human neural development. Engineered biomaterials have the ability to create more biomimetic neural microenvironments, but further refinement is required before widespread implementation.
Human pluripotent stem cells have emerged as a promising in vitro model system for studying the brain. Two-dimensional and three-dimensional cell culture paradigms have provided valuable insights into the pathogenesis of neuropsychiatric disorders, but they remain limited in their capacity to model certain features of human neural development. Specifically, current models do not efficiently incorporate extracellular matrix-derived biochemical and biophysical cues, facilitate multicellular spatio-temporal patterning, or achieve advanced functional maturation. Engineered biomaterials have the capacity to create increasingly biomimetic neural microenvironments, yet further refinement is needed before these approaches are widely implemented. This Review therefore highlights how continued progression and increased integration of engineered biomaterials may be well poised to address intractable challenges in recapitulating human neural development. Human pluripotent stem cell-derived in vitro models have potential as tools to study aspects of human brain development. Here, Heilshorn and colleagues review biomaterial-based approaches that may be integrated into these models in an effort to develop them further and better recapitulate neurodevelopmental processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available