Journal
NATURE REVIEWS GENETICS
Volume 22, Issue 8, Pages 477-478Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41576-021-00380-6
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Funding
- Wellcome Trust [203141/Z/16/Z, 212219/Z/18/Z]
- Medical Research Council Mitochondrial Biology Unit [MC_UU_00015/9]
- NIHR Biomedical Research Centres at Cambridge, Oxford and Great Ormond Street
- MRC [MC_UU_00015/9] Funding Source: UKRI
- Wellcome Trust [212219/Z/18/Z] Funding Source: Wellcome Trust
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Evidence for biparental inheritance of mitochondrial DNA (mtDNA) has been sparse and controversial. Recent studies do not support paternal transmission of mtDNA and suggest that previous observations may be explained by technical artifacts such as the co-amplification of rare, concatenated nuclear mtDNA segments.
Evidence for a biparental mode of mitochondrial DNA (mtDNA) inheritance has been sparse and remains controversial. Recent studies using a range of complementary techniques do not support paternal transmission of mtDNA and highlight the co-amplification of rare, concatenated nuclear mtDNA segments as a technical artefact that may explain previous observations. This Comment discusses recent studies supporting the existence of concatenated mitochondrial DNA (mtDNA) segments integrated into the nuclear genome, which may explain previous observations suggesting the existence of a biparental mode of mtDNA inheritance.
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