4.7 Review

Exploring liver cancer biology through functional genetic screens

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Exploring subclass-specific therapeutic agents for hepatocellular carcinoma by informatics-guided drug screen

Chen Yang et al.

Summary: By exploring tailored treatment strategies for different subtypes of HCC, certain drugs with potential therapeutic effects in specific subtypes were discovered, and novel therapeutic compounds not commonly used in clinics were identified, potentially changing the landscape of population-based therapies and offering new insights into precision oncology.

BRIEFINGS IN BIOINFORMATICS (2021)

Review Biochemistry & Molecular Biology

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

George M. Burslem et al.

Review Gastroenterology & Hepatology

Advances in molecular classification and precision oncology in hepatocellular carcinoma

Sandra Rebouissou et al.

JOURNAL OF HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

The landscape of gene mutations in cirrhosis and hepatocellular carcinoma

Miryam Müller et al.

JOURNAL OF HEPATOLOGY (2020)

Article Biochemical Research Methods

Analysis pipelines for cancer genome sequencing in mice

Sebastian Lange et al.

NATURE PROTOCOLS (2020)

Review Gastroenterology & Hepatology

Organoid models of gastrointestinal cancers in basic and translational research

Harry Cheuk Hay Lau et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Gastroenterology & Hepatology

Tumour evolution in hepatocellular carcinoma

Amanda J. Craig et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Multidisciplinary Sciences

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

Richard Y. Ebright et al.

SCIENCE (2020)

Article Cell & Tissue Engineering

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

Birgitta E. Michels et al.

CELL STEM CELL (2020)

Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer

Nicholas R. Perkons et al.

CLINICAL CANCER RESEARCH (2020)

Article Biochemistry & Molecular Biology

Genome-scale CRISPR activation screening identifies a role of LRP8 in Sorafenib resistance in Hepatocellular carcinoma

Jun Cai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Drug mechanism-of-action discovery through the integration of pharmacological andCRISPRscreens

Emanuel Goncalves et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Article Multidisciplinary Sciences

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson et al.

NATURE (2020)

Review Biochemistry & Molecular Biology

Designing custom CRISPR libraries for hypothesis-driven drug target discovery

Vaishnavi Srinivasan Iyer et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Review Oncology

In vivo functional screening for systems-level integrative cancer genomics

Julia Weber et al.

NATURE REVIEWS CANCER (2020)

Review Biochemistry & Molecular Biology

Computational approaches for effective CRISPR guide RNA design and evaluation

Guanqing Liu et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Review Gastroenterology & Hepatology

Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9

Julia E. Kieckhaefer et al.

SEMINARS IN LIVER DISEASE (2019)

Article Multidisciplinary Sciences

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

Edmond M. Chan et al.

NATURE (2019)

Article Multidisciplinary Sciences

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens

Fiona M. Behan et al.

NATURE (2019)

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Nadim Aizarani et al.

NATURE (2019)

Review Cell Biology

FGF19-FGFR4 Signaling in Hepatocellular Carcinoma

Aroosha Raja et al.

CELLS (2019)

Article Oncology

A Pharmacogenomic Landscape in Human Liver Cancers

Zhixin Qiu et al.

CANCER CELL (2019)

Article Medicine, General & Internal

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer

S. Kopetz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Multidisciplinary Sciences

Inducing and exploiting vulnerabilities for the treatment of liver cancer

Cun Wang et al.

NATURE (2019)

Review Multidisciplinary Sciences

A view on drug resistance in cancer

Neil Vasan et al.

NATURE (2019)

Article Gastroenterology & Hepatology

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

Jesse D. Riordan et al.

HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma

Mohamed Bouattour et al.

HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Mutational landscape of a chemically-induced mouse model of liver cancer

Frances Connor et al.

JOURNAL OF HEPATOLOGY (2018)

Article Medicine, General & Internal

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

G. K. Abou-Alfa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Cell Biology

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

Sandro Nuciforo et al.

CELL REPORTS (2018)

Article Multidisciplinary Sciences

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

Takahiro Kodama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Oncology

Cancer CRISPR Screens In Vivo

Ryan D. Chow et al.

TRENDS IN CANCER (2018)

Review Biotechnology & Applied Microbiology

Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution

Dirk Grimm et al.

HUMAN GENE THERAPY (2017)

Article Multidisciplinary Sciences

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

Riccardo Mezzadra et al.

NATURE (2017)

Article Multidisciplinary Sciences

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Marian L. Burr et al.

NATURE (2017)

Article Multidisciplinary Sciences

Identification of essential genes for cancer immunotherapy

Shashank J. Patel et al.

NATURE (2017)

Article Multidisciplinary Sciences

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Robert T. Manguso et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

Article Biochemical Research Methods

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Julia Joung et al.

NATURE PROTOCOLS (2017)

Review Genetics & Heredity

Synthetic lethality and cancer

Nigel J. O'Neil et al.

NATURE REVIEWS GENETICS (2017)

Article Multidisciplinary Sciences

piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice

Chunlong Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

Joseph Rosenbluh et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance

Carlos le Sage et al.

SCIENTIFIC REPORTS (2017)

Article Oncology

Preclinical mouse solid tumour models: status quo, challenges and perspectives

Nicolas Gengenbacher et al.

NATURE REVIEWS CANCER (2017)

Review Oncology

Drugging the 'undruggable' cancer targets

Chi V. Dang et al.

NATURE REVIEWS CANCER (2017)

Article Biochemistry & Molecular Biology

Defining a Cancer Dependency Map

Aviad Tsherniak et al.

Article Biochemistry & Molecular Biology

Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

Chunhong Zheng et al.

Review Biochemistry & Molecular Biology

Design, execution, and analysis of pooled in vitro CRISPR/Cas9 screens

Linde A. Miles et al.

FEBS JOURNAL (2016)

Article Biochemistry & Molecular Biology

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

Sergio Ruiz et al.

MOLECULAR CELL (2016)

Article Biotechnology & Applied Microbiology

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes

Bastiaan Evers et al.

NATURE BIOTECHNOLOGY (2016)

Article Biochemistry & Molecular Biology

A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer

Daniel Dauch et al.

NATURE MEDICINE (2016)

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Biotechnology & Applied Microbiology

CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries

Florian Heigwer et al.

GENOME BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Sidi Chen et al.

Article Gastroenterology & Hepatology

Genetic Landscape and Biomarkers of Hepatocellular Carcinoma

Jessica Zucman-Rossi et al.

GASTROENTEROLOGY (2015)

Article Medicine, Research & Experimental

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma

Lawrence N. Kwong et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Silvana Konermann et al.

NATURE (2015)

Article Oncology

Mouse hospital and co-clinical trial project-from bench to bedside

John G. Clohessy et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

Editorial Material Genetics & Heredity

An ecosystem of cancer cell line factories to support a cancer dependency map

Jesse S. Boehm et al.

NATURE REVIEWS GENETICS (2015)

Review Genetics & Heredity

High-throughput functional genomics using CRISPR-Cas9

Ophir Shalem et al.

NATURE REVIEWS GENETICS (2015)

Article Multidisciplinary Sciences

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

Julia Weber et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Identification and characterization of essential genes in the human genome

Tim Wang et al.

SCIENCE (2015)

Review Biochemistry & Molecular Biology

A co-clinical platform to accelerate cancer treatment optimization

Andrea Lunardi et al.

TRENDS IN MOLECULAR MEDICINE (2015)

Review Genetics & Heredity

A new age in functional genomics using CRISPR/Cas9 in arrayed library screening

Alexander Agrotis et al.

FRONTIERS IN GENETICS (2015)

Review Oncology

Therapeutic Targeting of Tumor Suppressor Genes

Luc G. T. Morris et al.

CANCER (2015)

Article Biochemistry & Molecular Biology

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

Edmond Chipumuro et al.

Article Biochemistry & Molecular Biology

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Luke A. Gilbert et al.

Article Biotechnology & Applied Microbiology

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

Hiroko Koike-Yusa et al.

NATURE BIOTECHNOLOGY (2014)

Article Genetics & Heredity

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

Yasushi Totoki et al.

NATURE GENETICS (2014)

Article Biochemistry & Molecular Biology

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer

Ramona Rudalska et al.

NATURE MEDICINE (2014)

Article Multidisciplinary Sciences

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

Tim Wang et al.

SCIENCE (2014)

Article Biochemistry & Molecular Biology

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Luke A. Gilbert et al.

Article Gastroenterology & Hepatology

Identification of Driver Genes in Hepatocellular Carcinoma by Exome Sequencing

Sean P. Cleary et al.

HEPATOLOGY (2013)

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

Article Biochemical Research Methods

CRISPR RNA-guided activation of endogenous human genes

Morgan L. Maeder et al.

NATURE METHODS (2013)

Article Multidisciplinary Sciences

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong et al.

SCIENCE (2013)

Review Biochemistry & Molecular Biology

RNA Polymerase II Elongation Control

Qiang Zhou et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Review Biotechnology & Applied Microbiology

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

Ryszard Kole et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Medicine, General & Internal

Survival in BRAF V600-Mutant Advanced Melanoma Treated with Vemurafenib

Jeffrey A. Sosman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Multidisciplinary Sciences

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jinek et al.

SCIENCE (2012)

Review Cell Biology

The Many Faces of RNAi

Rene F. Ketting

DEVELOPMENTAL CELL (2011)

Article Biochemical Research Methods

A public genome-scale lentiviral expression library of human ORFs

Xiaoping Yang et al.

NATURE METHODS (2011)

Review Oncology

Mitogen-activated protein kinases in hepatocellular carcinoma development

Lihua Min et al.

SEMINARS IN CANCER BIOLOGY (2011)

Article Oncology

The APL Paradigm and the Co-Clinical Trial Project

Caterina Nardella et al.

CANCER DISCOVERY (2011)

Review Biochemistry & Molecular Biology

Genomic Screening with RNAi: Results and Challenges

Stephanie Mohr et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)

Article Biochemistry & Molecular Biology

Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process

Emily M. LeProust et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Multidisciplinary Sciences

PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

Roland Rad et al.

SCIENCE (2010)

Review Multidisciplinary Sciences

The promises and pitfalls of RNA-interference-based therapeutics

Daniela Castanotto et al.

NATURE (2009)

Article Biotechnology & Applied Microbiology

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma

Vincent W. Keng et al.

NATURE BIOTECHNOLOGY (2009)

Review Biochemical Research Methods

Transposon-mediated genome manipulation in vertebrates

Zoltan Ivics et al.

NATURE METHODS (2009)

Article Oncology

Focal gains of VEGFA and molecular classification of hepatocellular carcinoma

Derek Y. Chiang et al.

CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

Lars Zender et al.

Review Genetics & Heredity

The art and design of genetic screens: RNA interference

Michael Boutros et al.

NATURE REVIEWS GENETICS (2008)

Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Review Biotechnology & Applied Microbiology

Hydrodynamic gene delivery: Its principles and applications

Takeshi Suda et al.

MOLECULAR THERAPY (2007)

Article Gastroenterology & Hepatology

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

Sandrine Boyault et al.

HEPATOLOGY (2007)

Article Biochemical Research Methods

Genome-scale loss-of-function screening with a lentiviral RNAi library

David E. Root et al.

NATURE METHODS (2006)

Article Biochemical Research Methods

shRNA libraries and their use in cancer genetics

Rene Bernards et al.

NATURE METHODS (2006)

Article Multidisciplinary Sciences

A resource for large-scale RNA-interference-based screens in mammals

PJ Paddison et al.

NATURE (2004)

Article Biotechnology & Applied Microbiology

Expression profiling reveals off-target gene regulation by RNAi

AL Jackson et al.

NATURE BIOTECHNOLOGY (2003)