4.6 Review

Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes - A longitudinal nationwide population-based study

Ho Youn Park et al.

Summary: The study revealed that individuals in prediabetes stage had an increased risk of hip fractures, which was linearly associated with the duration of T2DM. This trend was consistent across both sexes and all age groups.
Review Cell Biology

Lipids in the Bone Marrow: An Evolving Perspective

Elizabeth Rendina-Ruedy et al.

CELL METABOLISM (2020)

Article Endocrinology & Metabolism

Vertebral Fractures in Individuals With Type 2 Diabetes: More Than Skeletal Complications Alone

Fjorda Koromani et al.

DIABETES CARE (2020)

Review Biochemistry & Molecular Biology

Discovery, development, and future application of senolytics: theories and predictions

Erin O. Wissler Gerdes et al.

FEBS JOURNAL (2020)

Review Endocrinology & Metabolism

The role of cellular senescence in ageing and endocrine disease

Sundeep Khosla et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Article Endocrinology & Metabolism

HbA1c variability, in addition to mean HbA1c, predicts incident hip fractures in Chinese people with type 2 diabetes

D. T. W. Lui et al.

OSTEOPOROSIS INTERNATIONAL (2020)

Article Endocrinology & Metabolism

Sclerostin Regulation, Microarchitecture, and Advanced Glycation End-Products in the Bone of Elderly Women With Type 2 Diabetes

Alessandra Piccoli et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Article Endocrinology & Metabolism

Determinants of Bone Material Strength and Cortical Porosity in Patients with Type 2 Diabetes Mellitus

Parinya Samakkarnthai et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

Article Medicine, Research & Experimental

Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes

Brittany A. Eckhardt et al.

JCI INSIGHT (2020)

Article Endocrinology & Metabolism

Risk of fragility fractures in obesity and diabetes: a retrospective analysis on a nation-wide cohort

G. Adami et al.

OSTEOPOROSIS INTERNATIONAL (2020)

Article Medical Laboratory Technology

Development and Application of Mass Spectroscopy Assays for Nε-(1-Carboxymethyl)-L-Lysine and Pentosidine in Renal Failure and Diabetes

Katherine L. O'Grady et al.

JOURNAL OF APPLIED LABORATORY MEDICINE (2020)

Article Endocrinology & Metabolism

Effects of SGLT2 inhibitors on fractures and bone mineral density in type 2 diabetes: An updated meta-analysis

Xiaoyu Li et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2019)

Article Immunology

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Larissa G.P. Langhi Prata et al.

SEMINARS IN IMMUNOLOGY (2019)

Article Cell Biology

Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes

Cristina Aguayo-Mazzucato et al.

CELL METABOLISM (2019)

Review Endocrinology & Metabolism

Cellular senescence: at the nexus between ageing and diabetes

Allyson K. Palmer et al.

DIABETOLOGIA (2019)

Review Geriatrics & Gerontology

Effects of Statins on Relative Risk of Fractures for Older Adults: An Updated Systematic Review With Meta-Analysis

Rui Shi et al.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2019)

Review Endocrinology & Metabolism

The role of osteoblasts in energy homeostasis

Naomi Dirckx et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Endocrinology & Metabolism

Bone material strength in normoglycemic and hyperglycemic black and white older adults

B. Dawson-Hughes et al.

OSTEOPOROSIS INTERNATIONAL (2019)

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

Article Cell Biology

The bystander effect contributes to the accumulation of senescent cells in vivo

Paulo F. L. da Silva et al.

AGING CELL (2019)

Article Cell Biology

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Mikolaj Ogrodnik et al.

CELL METABOLISM (2019)

Article Endocrinology & Metabolism

Hypoglycaemia is associated with increased risk of fractures in patients with type 2 diabetes mellitus: a cohort study

Antiopi Ntouva et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

Article Medicine, General & Internal

Diabetes mellitus and the risk of fractures at specific sites: a meta-analysis

Hao Wang et al.

BMJ OPEN (2019)

Article Cell Biology

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Allyson K. Palmer et al.

AGING CELL (2019)

Article Endocrinology & Metabolism

Diabetes and Deficits in Cortical Bone Density, Microarchitecture, and Bone Size: Framingham HR-pQCT Study

Elizabeth J. Samelson et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

Article Endocrinology & Metabolism

Vertebral Fracture Risk in Diabetic Elderly Men: The MrOS Study

Nicola Napoli et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

Article Endocrinology & Metabolism

Effect of denosumab on fasting glucose in women with diabetes or prediabetes from the FREEDOM trial

Nicola Napoli et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2018)

Article Endocrinology & Metabolism

Robust Trabecular Microstructure in Type 2 Diabetes Revealed by Individual Trabecula Segmentation Analysis of HR-pQCT Images

Jessica F. Starr et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

Review Geriatrics & Gerontology

Glycation Damage: A Possible Hub for Major Pathophysiological Disorders and Aging

Maxime Fournet et al.

AGING AND DISEASE (2018)

Article Endocrinology & Metabolism

Sitagliptin and risk of fractures in type 2 diabetes: Results from the TECOS trial

Robert G. Josse et al.

DIABETES OBESITY & METABOLISM (2017)

Review Endocrinology & Metabolism

Mechanisms of diabetes mellitus-induced bone fragility

Nicola Napoli et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Endocrinology & Metabolism

The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial

Karen C. Johnson et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

Article Endocrinology & Metabolism

Bone Turnover Is Suppressed in Insulin Resistance, Independent of Adiposity

Katherine T. Tonks et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Biochemistry & Molecular Biology

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr et al.

NATURE MEDICINE (2017)

Article Endocrinology & Metabolism

Severe hypoglycemia and hip fracture in patients with type 2 diabetes: a nationwide population-based cohort study

Y. C. Hung et al.

OSTEOPOROSIS INTERNATIONAL (2017)

Article Multidisciplinary Sciences

Cellular senescence drives age-dependent hepatic steatosis

Mikolaj Ogrodnik et al.

NATURE COMMUNICATIONS (2017)

Review Cardiac & Cardiovascular Systems

The Impact of Antihypertensive Medications on Bone Mineral Density and Fracture Risk

Joshua I. Barzilay et al.

CURRENT CARDIOLOGY REPORTS (2017)

Article Multidisciplinary Sciences

Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis

Eladio Losada-Grande et al.

SCIENTIFIC REPORTS (2017)

Article Endocrinology & Metabolism

Bone Microarchitecture in Men and Women with Diabetes: The Importance of Cortical Porosity

Julien Paccou et al.

CALCIFIED TISSUE INTERNATIONAL (2016)

Article Endocrinology & Metabolism

Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease

Vikram V. Shanbhogue et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2016)

Review Pharmacology & Pharmacy

The multiple faces of RAGE - opportunities for therapeutic intervention in aging and chronic disease

Ravichandran Ramasamy et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2016)

Article Endocrinology & Metabolism

Diabetes mellitus and risk of hip fractures: a meta-analysis

Y. Fan et al.

OSTEOPOROSIS INTERNATIONAL (2016)

Review Endocrinology & Metabolism

Determinants of bone strength and quality in diabetes mellitus in humans

Joshua N. Farr et al.

Review Endocrinology & Metabolism

Biochemical bone turnover markers in diabetes mellitus - A systematic review

Jakob Starup-Linde et al.

Article Endocrinology & Metabolism

Regulation of Glucose Handling by the Skeleton: Insights From Mouse and Human Studies

Jian-Min Liu et al.

DIABETES (2016)

Article Endocrinology & Metabolism

Glycemic control and fracture risk in elderly patients with diabetes

Baqiyyah N. Conway et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2016)

Review Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Thomas A. Wynn et al.

IMMUNITY (2016)

Article Endocrinology & Metabolism

Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes

Jessica R. Furst et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Article Endocrinology & Metabolism

Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus

Nelson B. Watts et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2016)

Review Endocrinology & Metabolism

Type 2 diabetes and the skeleton: new insights into sweet bones

Vikram V. Shanbhogue et al.

LANCET DIABETES & ENDOCRINOLOGY (2016)

Editorial Material Cell Biology

Repurposing an Osteoporosis Drug for β Cell Regeneration in Diabetic Patients

Felizitas Schmitz et al.

CELL METABOLISM (2015)

Article Pharmacology & Pharmacy

Emerging Targets for Therapeutic Development in Diabetes and Its Complications: The RAGE Signaling Pathway

E. M. S. Litwinoff et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

Article Endocrinology & Metabolism

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Allyson K. Palmer et al.

DIABETES (2015)

Article Endocrinology & Metabolism

Incidence of Fractures in Patients With Type 2 Diabetes in the SAVOR-TIMI 53 Trial

Ofri Mosenzon et al.

DIABETES CARE (2015)

Article Endocrinology & Metabolism

Sulfonylureas and risk of falls and fractures among nursing home residents with type 2 diabetes mellitus

Kate L. Lapane et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2015)

Review Pharmacology & Pharmacy

Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease

Douglas Walker et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2015)

Article Endocrinology & Metabolism

Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights

Beata Lecka-Czernik et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Article Endocrinology & Metabolism

Effects of TZD Use and Discontinuation on Fracture Rates in ACCORD Bone Study

Ann V. Schwartz et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)

Article Engineering, Biomedical

A direct role of collagen glycation in bone fracture

Atharva A. Poundarik et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2015)

Review Endocrinology & Metabolism

Oral anti-diabetic drugs and fracture risk, cut to the bone: safe or dangerous? A narrative review

A. Palermo et al.

OSTEOPOROSIS INTERNATIONAL (2015)

Review Endocrinology & Metabolism

RANKL/OPG; Critical role in bone physiology

T. John Martin et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2015)

Review Pharmacology & Pharmacy

Soluble RAGEs - Prospects for treating & tracking metabolic and inflammatory disease

Ann Marie Schmidt

VASCULAR PHARMACOLOGY (2015)

Article Endocrinology & Metabolism

Defects in cortical microarchitecture among African-American women with type 2 diabetes

E. W. Yu et al.

OSTEOPOROSIS INTERNATIONAL (2015)

Review Orthopedics

Assessment of bone vascularization and its role in bone remodeling

Marie-Helene Lafage-Proust et al.

BONEKEY REPORTS (2015)

Article Peripheral Vascular Disease

Screening Low-Risk Individuals for Coronary Artery Disease

Chintan S. Desai et al.

CURRENT ATHEROSCLEROSIS REPORTS (2014)

Article Endocrinology & Metabolism

Fracture risk in diabetic elderly men: the MrOS study

Nicola Napoli et al.

DIABETOLOGIA (2014)

Article Endocrinology & Metabolism

Cortical Porosity Identifies Women With Osteopenia at Increased Risk for Forearm Fractures

Yohann Bala et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Endocrinology & Metabolism

Risedronate Slows or Partly Reverses Cortical and Trabecular Microarchitectural Deterioration in Postmenopausal Women

Yohann Bala et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Endocrinology & Metabolism

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes

Joshua N. Farr et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Endocrinology & Metabolism

Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women

Yu-Heng Vivian Ma et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Article Clinical Neurology

Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease

Douglas Galasko et al.

NEUROLOGY (2014)

Article Endocrinology & Metabolism

Clinician's Guide to Prevention and Treatment of Osteoporosis

F. Cosman et al.

OSTEOPOROSIS INTERNATIONAL (2014)

Review Cell Biology

Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors

Christian Rask-Madsen et al.

CELL METABOLISM (2013)

Article Endocrinology & Metabolism

Diabetes and Risk of Fracture-Related Hospitalization

Andrea L. C. Schneider et al.

DIABETES CARE (2013)

Article Endocrinology & Metabolism

Tricyclic antidepressant use and risk of fractures: A meta-analysis of cohort and case-control studies

Qing Wu et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2013)

Article Endocrinology & Metabolism

Increased Cortical Porosity in Type 2 Diabetic Postmenopausal Women With Fragility Fractures

Janina M. Patsch et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2013)

Review Endocrinology & Metabolism

Marrow Fat and Bone-New Perspectives

Pouneh K. Fazeli et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Endocrinology & Metabolism

TBS (Trabecular Bone Score) and Diabetes-Related Fracture Risk

William D. Leslie et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Cell Biology

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Juan Carlos Acosta et al.

NATURE CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

WNT signaling in bone homeostasis and disease: from human mutations to treatments

Roland Baron et al.

NATURE MEDICINE (2013)

Article Cell Biology

A senescent cell bystander effect: senescence-induced senescence

Glyn Nelson et al.

AGING CELL (2012)

Article Endocrinology & Metabolism

Association between hypoglycaemic events and fall-related fractures in Medicare-covered patients with type 2 diabetes

S. S. Johnston et al.

DIABETES OBESITY & METABOLISM (2012)

Review Public, Environmental & Occupational Health

Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies

Lili Ma et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2012)

Article Endocrinology & Metabolism

Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes

Luigi Gennari et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Article Endocrinology & Metabolism

Circulating Osteogenic Precursor Cells in Type 2 Diabetes Mellitus

J. S. Manavalan et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Review Rheumatology

The skeleton as an endocrine organ

Douglas J. DiGirolamo et al.

NATURE REVIEWS RHEUMATOLOGY (2012)

Article Endocrinology & Metabolism

Bone structure and turnover in type 2 diabetes mellitus

A. Shu et al.

OSTEOPOROSIS INTERNATIONAL (2012)

Article Endocrinology & Metabolism

Dipeptidyl Peptidase-4 Inhibitors and Bone Fractures A meta-analysis of randomized clinical trials

Matteo Monami et al.

DIABETES CARE (2011)

Article Endocrinology & Metabolism

Improvements in life expectancy in adult type 2 diabetes patients in the last six decades

Sorin Ioacara et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2011)

Article Medicine, General & Internal

Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes

Ann V. Schwartz et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Review Cell Biology

Fat tissue, aging, and cellular senescence

Tamara Tchkonia et al.

AGING CELL (2010)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Endocrinology & Metabolism

Activin A Plays a Critical Role in Proliferation and Differentiation of Human Adipose Progenitors

Laure-Emmanuelle Zaragosi et al.

DIABETES (2010)

Article Endocrinology & Metabolism

Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states

Bernardo Nuche-Berenguer et al.

REGULATORY PEPTIDES (2010)

Article Pathology

A Physical Mechanism for Coupling Bone Resorption and Formation in Adult Human Bone

Thomas Levin Andersen et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

Article Endocrinology & Metabolism

Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone Regeneration

Celine Colnot

JOURNAL OF BONE AND MINERAL RESEARCH (2009)

Article Endocrinology & Metabolism

Pentosidine and Increased Fracture Risk in Older Adults with Type 2 Diabetes

Ann V. Schwartz et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Endocrinology & Metabolism

Fracture risk in type 2 diabetes: Update of a population-based study

L. Joseph I. I. I. I. Melton et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2008)

Article Endocrinology & Metabolism

FRAX™ and the assessment of fracture probability in men and women from the UK

J. A. Kanis et al.

OSTEOPOROSIS INTERNATIONAL (2008)

Article Endocrinology & Metabolism

Bone Fractures and Hypoglycemic Treatment in Type 2 Diabetic Patients A case-control study

Matteo Monami et al.

DIABETES CARE (2008)

Review Public, Environmental & Occupational Health

Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture

Mohsen Janghorbani et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2007)

Article Endocrinology & Metabolism

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans

Luigi Fontana et al.

DIABETES (2007)

Article Endocrinology & Metabolism

Risk of fracture in women with type 2 diabetes: The Women's Health Initiative Observational Study

Denise E. Bonds et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Immunology

Regulation of osteoclast function and bone mass by RAGE

Z Zhou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Article Biochemistry & Molecular Biology

Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss

KH Ding et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Endocrinology & Metabolism

Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues

KM Thrailkill et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)

Article Endocrinology & Metabolism

Simple non-invasive assessment of advanced glycation endproduct accumulation

R Meerwaldt et al.

DIABETOLOGIA (2004)

Article Biochemistry & Molecular Biology

Reversal of human cellular senescence:: roles of the p53 and p16 pathways

CM Beauséjour et al.

EMBO JOURNAL (2003)

Article Endocrinology & Metabolism

Older women with diabetes have a higher risk of falls

AV Schwartz et al.

DIABETES CARE (2002)

Article Medicine, Research & Experimental

Insulin receptor substrate-1 in osteoblast is indispensible for maintaining bone turnover

N Ogata et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

Article Medicine, Research & Experimental

Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice

E Lalla et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

Article Endocrinology & Metabolism

Correlations between insulin sensitivity and bone mineral density in non-diabetic men

B Abrahamsen et al.

DIABETIC MEDICINE (2000)