Exercise mimetics: harnessing the therapeutic effects of physical activity

Physical activity has demonstrated positive effects in preventing and ameliorating a broad range of diseases, particularly central nervous system disorders. Accordingly, strategies to therapeutically mimic the effects of exercise are gaining interest. Here, Gubert and Hannan focus on the molecular and cellular effects of physical activity in the central nervous system, assessing opportunities for the development of therapeutic exercise mimetics. Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance the therapeutic effects of exercise. Increased physical activity has demonstrated positive effects in preventing and ameliorating a wide range of diseases, including brain disorders such as Alzheimer disease and dementia, cancer, diabetes and cardiovascular disease. This article discusses the molecular mechanisms and signalling pathways associated with the beneficial effects of physical activity, focusing on effects on brain function and cognitive enhancement. Emerging therapeutic targets and strategies for the development of exercise mimetics, particularly in the field of central nervous system disorders, as well as the associated opportunities and challenges, are discussed.

Automated summary

Physical activity has shown positive effects in preventing and improving a wide range of diseases, particularly central nervous system disorders. The article discusses the molecular mechanisms and signaling pathways associated with the beneficial effects of physical activity, focusing on brain function and cognitive enhancement. Emerging therapeutic targets and strategies for the development of exercise mimetics in the field of central nervous system disorders are also explored.