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ACS CHEMICAL BIOLOGY (2013)
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
Luke R. G. Pike et al.
BIOCHEMICAL JOURNAL (2013)
Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity
Andrea Casazza et al.
CANCER CELL (2013)
Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Veronica Estrella et al.
CANCER RESEARCH (2013)
In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
Paulo A. Gameiro et al.
CELL METABOLISM (2013)
SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase
Murilo T. D. Bueno et al.
EPIGENETICS (2013)
Zinc Finger Nuclease Knock-out of NADPH: Cytochrome P450 Oxidoreductase (POR) in Human Tumor Cell Lines Demonstrates That Hypoxia-activated Prodrugs Differ in POR Dependence
Jiechuang Su et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Two phases of disulfide bond formation have differing requirements for oxygen
Marianne Koritzinsky et al.
JOURNAL OF CELL BIOLOGY (2013)
Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers
Rakesh K. Jain
JOURNAL OF CLINICAL ONCOLOGY (2013)
Comprehensivemolecular characterization of clear cell renal cell carcinoma
Chad J. Creighton et al.
NATURE (2013)
The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells
Tor-Christian Aase Johannessen et al.
NEURO-ONCOLOGY (2013)
PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS
Kasper M. Rouschop et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The Roles of Reactive Oxygen Species and Autophagy in Mediating the Tolerance of Tumor Cells to Cycling Hypoxia
Marianne Koritzinsky et al.
SEMINARS IN RADIATION ONCOLOGY (2013)
Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer
Veronique M. Neumeister et al.
BREAST CANCER RESEARCH AND TREATMENT (2012)
Chromatin as an oxygen sensor and active player in the hypoxia response
Andrew Melvin et al.
CELLULAR SIGNALLING (2012)
A Strategy for Selective O6-Alkylguanine-DNA Alkyltransferase Depletion Under Hypoxic Conditions
Philip G. Penketh et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2012)
The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under Hypoxia
Jingli Wang et al.
CLINICAL CANCER RESEARCH (2012)
Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain
Eliska Svastova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial
Geert O. Janssens et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Molecular and Cellular Pharmacology of the Hypoxia-Activated Prodrug TH-302
Fanying Meng et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Andrew R. Mullen et al.
NATURE (2012)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo et al.
NATURE (2012)
Oxygen Gas-Filled Microparticles Provide Intravenous Oxygen Delivery
John N. Kheir et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Passing the baton: the HIF switch
Mei Yee Koh et al.
TRENDS IN BIOCHEMICAL SCIENCES (2012)
Diflavin Oxidoreductases Activate the Bioreductive Prodrug PR-104A under Hypoxia
Christopher P. Guise et al.
MOLECULAR PHARMACOLOGY (2012)
Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer
Kasper Toustrup et al.
CANCER RESEARCH (2011)
Clinical trials of antioxidants as cancer prevention agents: Past, present, and future
Michael Goodman et al.
FREE RADICAL BIOLOGY AND MEDICINE (2011)
HYPOFRACTIONATION RESULTS IN REDUCED TUMOR CELL KILL COMPARED TO CONVENTIONAL FRACTIONATION FOR TUMORS WITH REGIONS OF HYPOXIA
David J. Carlson et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)
Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis
Fabio Pacchiano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
Paul T. Mungai et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
Galina A. Gusarova et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment
Jonathan W. Wojtkowiak et al.
MOLECULAR PHARMACEUTICS (2011)
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Andrea Facciabene et al.
NATURE (2011)
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck - A systematic review and meta-analysis
Jens Overgaard
RADIOTHERAPY AND ONCOLOGY (2011)
Targeting hypoxia in cancer therapy
William R. Wilson et al.
NATURE REVIEWS CANCER (2011)
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene
F. M. Buffa et al.
BRITISH JOURNAL OF CANCER (2010)
The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3
Christopher P. Guise et al.
CANCER RESEARCH (2010)
Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability
Isabel M. Pires et al.
CANCER RESEARCH (2010)
Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment
Norman Chan et al.
CANCER RESEARCH (2010)
Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
Kevin O. Hicks et al.
CLINICAL CANCER RESEARCH (2010)
Targeting Hypoxic Cells through the DNA Damage Response
Monica Olcina et al.
CLINICAL CANCER RESEARCH (2010)
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
Norihiko Takeda et al.
GENES & DEVELOPMENT (2010)
STEREOTACTIC ABLATIVE RADIOTHERAPY SHOULD BE COMBINED WITH A HYPOXIC CELL RADIOSENSITIZER
J. Martin Brown et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2010)
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
Mitomu Kioi et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Radiotherapy With Concurrent Carbogen and Nicotinamide in Bladder Carcinoma
Peter J. Hoskin et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Critical Impact of Radiotherapy Protocol Compliance and Quality in the Treatment of Advanced Head and Neck Cancer: Results From TROG 02.02
Lester J. Peters et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (vol 462, pg 739, 2010)
Lenny Dang et al.
NATURE (2010)
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130
Denise Campisi Hegan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
Ian F. Robey et al.
CANCER RESEARCH (2009)
Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A
Yongchuan Gu et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress
Mark W. Dewhirst
RADIATION RESEARCH (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: Role of bone marrow-derived myelomonocytic cells
G-One Ahn et al.
CANCER CELL (2008)
HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
Rose Du et al.
CANCER CELL (2008)
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance
Norman Chan et al.
CANCER RESEARCH (2008)
Amplifying tumour-specific replication lesions by DNA repair inhibitors - A new era in targeted cancer therapy
Thomas Helleday
EUROPEAN JOURNAL OF CANCER (2008)
Efficacy of novel hypoxic cell sensitiser doranidazole in the treatment of locally advanced pancreatic cancer: Long-term results of a placebo-control led randomised study
Katsuyuki Karasawa et al.
RADIOTHERAPY AND ONCOLOGY (2008)
Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: Comparison of the dinitrobenzamide mustard PR-104A and tirapazamine
Kevin O. Hicks et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)
Chemical radiosensitizers for use in radiotherapy
P. Wardman
CLINICAL ONCOLOGY (2007)
Detection and characterization of tumor hypoxia using pO2 histography
Peter Vaupel et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104
Adam V. Patterson et al.
CLINICAL CANCER RESEARCH (2007)
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
R. S. Bindra et al.
ONCOGENE (2007)
The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
William G. Kaelin
CLINICAL CANCER RESEARCH (2007)
Hypoxia in head and neck cancer: Studies with hypoxic positron emission tomography imaging and hypoxic cytotoxins
Danny Rischin et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)
Bystander effects of bioreductive drugs: Potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards
William R. Wilson et al.
RADIATION RESEARCH (2007)
Hypoxia-inducible factor-1 mediates the expression of DNA polymerase ι in human tumor cells
Akiko Ito et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
Michael R. Mancuso et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs
Kevin O. Hicks et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)
Succinate dehydrogenase and fumarate hydratase:: linking mitochondrial dysfunction and cancer
A. King et al.
ONCOGENE (2006)
Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine:: A substudy of Trans-Tasman Radiation Oncology Group study 98.02
D Rischin et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics
LE Gerweck et al.
MOLECULAR CANCER THERAPEUTICS (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Hypoxia-induced down-regulation of BRCA1 expression by E2Fs
RS Bindra et al.
CANCER RESEARCH (2005)
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
M Nordsmark et al.
RADIOTHERAPY AND ONCOLOGY (2005)
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
HE Bryant et al.
NATURE (2005)
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
H Farmer et al.
NATURE (2005)
Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: A randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02)
D Rischin et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
A dynamic equilibrium between CDKs and PP2A modulates phosphorylation of pRB, p107 and p130
J Garriga et al.
CELL CYCLE (2004)
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
DJ Ceradini et al.
NATURE MEDICINE (2004)
Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides
SS Shinde et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for extravascular transport and activity in tumors
KO Hicks et al.
RADIATION RESEARCH (2004)
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
BJ Moeller et al.
CANCER CELL (2004)
Tumor response to radiotherapy regulated by endothelial cell apoptosis
M Garcia-Barros et al.
SCIENCE (2003)
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
EM Hammond et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The mechanism of action of radios ensitization of conventional chemotherapeutic agents
TS Lawrence et al.
SEMINARS IN RADIATION ONCOLOGY (2003)
Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α
C Koumenis et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone EO9 to free radical and DNA damaging species
SM Bailey et al.
BIOCHEMICAL PHARMACOLOGY (2001)
AQ4N: a new approach to hypoxia-activated cancer chemotherapy
LH Patterson et al.
BRITISH JOURNAL OF CANCER (2000)