Journal
NATURE NANOTECHNOLOGY
Volume 16, Issue 8, Pages 942-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41565-021-00923-2
Keywords
-
Funding
- National Institutes of Health [HL123920, HL137093, HL144002, HL146153, HL147357, HL149940]
- American Heart Association [18TPA34230092, 19EIA34660286]
- State of North Carolina
- National Science Foundation [ECCS-1542015, DMR-1726294]
Ask authors/readers for more resources
The authors demonstrate that nanovesicles coated with lung spheroid cell membranes expressing angiotensin-converting enzyme 2 can bind and neutralize SARS-CoV-2, potentially serving as a therapeutic agent for treating COVID-19.
In this paper the authors show that nanovesicles coated with lung spheroid cell membranes expressing angiotensin-converting enzyme 2 can bind the spike protein of SARS-CoV-2, neutralizing the virus and preventing lung cell infections in murine and non-human primate models. The nanodecoys could represent a potential therapeutic agent to treat COVID-19. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has grown into a global pandemic, and only a few antiviral treatments have been approved to date. Angiotensin-converting enzyme 2 (ACE2) plays a fundamental role in SARS-CoV-2 pathogenesis because it allows viral entry into host cells. Here we show that ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2 and protect the host lung cells from infection. In mice, these LSC-nanodecoys were delivered via inhalation therapy and resided in the lungs for over 72 h post-delivery. Furthermore, inhalation of the LSC-nanodecoys accelerated clearance of SARS-CoV-2 mimics from the lungs, with no observed toxicity. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of these nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. Our results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available