Journal
NATURE IMMUNOLOGY
Volume 22, Issue 6, Pages 673-674Publisher
NATURE RESEARCH
DOI: 10.1038/s41590-021-00946-w
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Funding
- National Health and Medical Research Council (NHMRC), Australia [1175411]
- NHMRC [1185294, 2002393]
- National Health and Medical Research Council of Australia [2002393, 1185294, 1175411] Funding Source: NHMRC
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B cells reprogram complement to enhance germinal center responses. However, when B cell C3 activity is restricted, germinal centers collapse leading to impaired outputs.
B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.
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