Journal
NATURE IMMUNOLOGY
Volume 22, Issue 10, Pages 1219-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41590-021-01027-8
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Research found that cancer resistance in blind mole rats is mediated by retrotransposable elements, which function by activating cell death pathways. While this mechanism is more prominent in blind mole rats, similar effects were observed in mice and humans.
Blind mole rats (BMRs) are small rodents, characterized by an exceptionally long lifespan (>21 years) and resistance to both spontaneous and induced tumorigenesis. Here we report that cancer resistance in the BMR is mediated by retrotransposable elements (RTEs). Cells and tissues of BMRs express very low levels of DNA methyltransferase 1. Following cell hyperplasia, the BMR genome DNA loses methylation, resulting in the activation of RTEs. Upregulated RTEs form cytoplasmic RNA-DNA hybrids, which activate the cGAS-STING pathway to induce cell death. Although this mechanism is enhanced in the BMR, we show that it functions in mice and humans. We propose that RTEs were co-opted to serve as tumor suppressors that monitor cell proliferation and are activated in premalignant cells to trigger cell death via activation of the innate immune response. Activation of RTEs is a double-edged sword, serving as a tumor suppressor but contributing to aging in late life via the induction of sterile inflammation. Blind mole rats are small rodents characterized by an exceptionally long lifespan and resistance to both spontaneous and induced tumorigenesis. Gorbunova and colleagues show that a transposon-triggered innate immune response confers cancer resistance to the blind mole rat.
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