Lighting up cholecystokinin

Targeting cholecystokinin receptors (CCKRs) signaling has become an attractive therapeutic strategy for many diseases. The description of cryo-EM structures of CCKRs in the active or inactive states reveal the molecular mechanism of ligand recognition and G-protein-coupling promiscuity.

Automated summary

The description of cryo-EM structures of CCKRs in active or inactive states provides insights into the molecular mechanisms of ligand recognition and G-protein-coupling, which can be utilized in developing therapeutic strategies targeting CCKRs signaling.