Journal
NATURE CHEMICAL BIOLOGY
Volume 17, Issue 12, Pages 1213-1214Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41589-021-00857-9
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The description of cryo-EM structures of CCKRs in active or inactive states provides insights into the molecular mechanisms of ligand recognition and G-protein-coupling, which can be utilized in developing therapeutic strategies targeting CCKRs signaling.
Targeting cholecystokinin receptors (CCKRs) signaling has become an attractive therapeutic strategy for many diseases. The description of cryo-EM structures of CCKRs in the active or inactive states reveal the molecular mechanism of ligand recognition and G-protein-coupling promiscuity.
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