Journal
NATURE CELL BIOLOGY
Volume 23, Issue 8, Pages 822-833Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41556-021-00721-x
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Funding
- Intramural Research Program of the National Institutes of Health at the National Institute of Neurological Disorders and Stroke
- National Heart, Lung, and Blood Institute of the National Institutes of Health [R01HL119215]
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Complex organoids play important roles in studying SARS-CoV-2 infection, modeling COVID-19 pathology, and developing drugs, antibodies, and vaccines. There are significant opportunities and challenges in the application of organoids in COVID-19 research.
Studying SARS-CoV-2 in organoids. Chen et al. review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to capture the extensive heterogeneity of the disease with conventional methods. Here we review the emerging roles of complex organoids in the study of SARS-CoV-2 infection, modelling of COVID-19 disease pathology and in drug, antibody and vaccine development. We discuss opportunities for COVID-19 research and remaining challenges in the application of organoids.
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