Journal
NATURE CELL BIOLOGY
Volume 23, Issue 8, Pages 816-817Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41556-021-00730-w
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- Biotechnology and Biological Sciences Research Council [BB/M001873/1] Funding Source: Medline
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Through chromatin accessibility analysis, the researchers found that inactivation of LKB1 resulted in overexpression of the Sox17 gene, which promotes lung cancer metastasis.
LKB1 is frequently mutated in lung, cervical and other types of cancers. To determine how LKB1 inactivation contributes to lung cancer progression, Pierce et al. employed a chromatin accessibility assay to reveal Sox17 as a key transcription factor downstream of LKB1, promoting lung cancer metastasis.
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