A new diterpenoid alkaloid from Delphinium gyalanum C. Marquand & Airy Shaw

A new C-19-diterpenoid alkaloid named gyalanutine A (1) and fourteen known compounds 2-15 were isolated from the plant of Delphinium gyalanum C. Marquand & Airy Shaw. Compound 1 displayed an unusual lycoctonine-type C-19-diterpenoid alkaloid skeleton with the cleavage of N-C-19 and C-7-C-17 bonds, and the construction of the N-C-7 bond. Structures were identified by multiple spectroscopic analyses including 1 D, 2 D NMR, IR and HR-ESI-MS. Compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.

Automated summary

A new C-19-diterpenoid alkaloid named gyalanutine A and fourteen known compounds were isolated from the plant of Delphinium gyalanum. The structure of gyalanutine A was determined to have an unusual lycoctonine-type skeleton. The compounds were tested for acetylcholinesterase inhibitory and anti-inflammatory activity.