Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 16, Pages 4205-4209Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1971977
Keywords
Scutellaria nepetifolia; 6 beta-hydroxy 8-epiboshnaloside; 1,5,9-epideoxy loganic acid; Verbascoside; INOS; molecular docking simulation; PC12
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Funding
- Shahid Beheshti University of Medical Sciences, Tehran, Iran [99-16862]
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The study isolated chemical compounds from the endemic species Scutellaria nepetifolia in Iran, and revealed through molecular docking study that two iridoid compounds showed strong interactions with iNOS protein, potentially contributing to its antioxidant effects.
Based on the long history of Scutellaria plants in east traditional medicines, several species of Scutellaria showed promising antioxidant, anti-inflammation and neuroprotection effects in pharmacological researches. Using bioassay-guided fractionation of various extract of Scutellaria nepetifolia, an endemic species that grows widely in Iran, based on on nitric oxide (NO) inhibitory activity against H2O2 induced NO production in PC12 pheochromocytoma cells led to the isolation of two iridoid compounds namely, as 6 beta-hydroxy 8-epiboshnaloside (1) and 1,5,9-epideoxy loganic acid (2) and Verbascoside (3). Finally, the interaction of isolated compounds with inducible nitric oxide synthase (iNOS) protein was simulated by molecular docking study. It is the first report of these two iridoid glycosides from Scutellaria spp. All three isolated compounds showed strong interaction with iNOS enzyme in molecular docking simulations. So, they possibly contributed in the NO inhibitory effect of S. nepetifolia.
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