Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 10, Pages 2643-2647Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1915306
Keywords
Staphylococcus aureus; Hypericum brasiliense; MIC; MBC; biofilm
Categories
Funding
- CAPES
- CNPq
- FAPERJ
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
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In this study, the Hypericum brasiliense extract exhibited bactericidal activity against a multidrug-resistant S. aureus strain and inhibited biofilm formation. These promising results suggest that Hypericum brasiliense extract could be a strong candidate for treating S. aureus infections, including anti-biofilm therapy.
Staphylococcus aureus is considered the most common opportunistic pathogen in humans, capable of forming biofilm, increasing the chances of antibiotic resistance and causes several chronic diseases. Biodiversity is a source of inspiration in the search for new agents against these microorganisms. Hitherto, the efficacy of Hypericum sp. extracts as an antibacterial agent has already been demonstrated against Gram-positive and Gram-negative bacteria. In this study, we observed that until 4 mu g/mL, the Hypericum brasiliense extract showed bactericidal activity against a clinical multidrug-resistant S. aureus strain (HU25) and also inhibited biofilm formation at 1/2xMIC (confirmed by SEM) and 1/4xMIC. The extract was also proportionally active against 6 h-preformed biofilm to its concentration (1/2xMIC, 1/4xMIC, p value <= 0.05). These promising results make Hypericum brasiliense extract a strong candidate to treat S. aureus infections, including anti-biofilm therapy.
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