New azaphilones from mangrove endophytic fungus Penicillium sclerotiorin SCNU-F0040

Two new sclerotioramines (1 and 2) and a new natural product of sclerotioramine analog (3), together with seven known compounds have been isolated from the mangrove endophytic fungus Penicillium sclerotiorin SCNU-F0040. Their structures were identified based on the 1 D, 2 D NMR and HRESIM spectra. The absolute configurations of new compounds were deduced by specific rotation data and electronic circular dichroism spectra. All the isolated new compounds were tested on anti-diabetes activity by using a-glucosidase inhibition assay and anti-inflammatory activity by using cyclooxygenase inhibition assay, respectively. Compounds 1 and 2 have a-glucosidase inhibition activity with IC50 values of 102.3 and 217.5 mu M. Compound 2 shows a moderate cyclooxygenase-2 inhibitory activity with an IC50 value of 47.8 mu M.

Automated summary

Two new sclerotioramines and a new natural product of sclerotioramine analog, along with seven known compounds, were isolated from the mangrove endophytic fungus Penicillium sclerotiorin SCNU-F0040. The structures of these compounds were determined through spectroscopic analysis, and the absolute configurations were determined using specific rotation data and electronic circular dichroism spectra. The new compounds were tested for their anti-diabetes and anti-inflammatory activities, with compounds 1 and 2 showing potent α-glucosidase inhibition activity.