Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 20, Pages 5255-5262Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1929974
Keywords
Chloranthus multistachys Pei; sesquiterpene; enantiomer; anti-inflammatory
Categories
Funding
- National Natural Science Foundation of China [82060697]
- Doctoral Research Initiation Fund of Jiangxi University of Chinese Medicine [2018BSZR003]
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Phytochemical investigation on Chloranthus multistachys Pei led to the discovery of three pairs of new sesquiterpene enantiomers, whose structures and configurations were determined by various techniques. However, these compounds did not show anti-inflammatory activity according to the evaluation using the RAW 264.7 macrophage inflammatory model.
Phytochemical investigation on the whole plant of Chloranthus multistachys pei (Chloranthaceae) afforded three pairs of new sesquiterpene enantiomers (+)/(-)-chlorantene M [(+)/(-)-1], (+)/(-)-chlorantene M1 [(+)/(-)-2] and (+)/(-)-chlorantene N [(+)/(-)-3]. The structures of new compounds were determined through spectroscopic techniques (HR-ESI-MS, 1 D and 2 D NMR), besides, their absolute and relative configurations were established by using Single-crystal X-ray diffraction analysis and CD spectrum. The anti-inflammatory potential of all compounds was evaluated by applying LPS induced RAW 264.7 macrophage inflammatory model, and the results were that none of these compounds showed activity (IC50 > 100 mu M).
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