Journal
NANOMEDICINE
Volume 16, Issue 19, Pages 1657-1671Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0472
Keywords
carbon dots; gastric ulcers; Nelumbinis Rhizomatis Nodus; potential mechanism
Funding
- Special Funds for Fundamental Research Expenses of Central Universities (China)
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Nelumbinis Rhizomatis Nodus carbon dots (NRN-CDs) show significant gastroprotective effects on ethanol-induced gastric ulcers in rats, potentially through the regulation of oxidative stress and inflammatory factors. NRN-CDs could be developed as a promising drug for the treatment of gastric ulcers.
Aim: To evaluate the gastroprotective effects of Nelumbinis Rhizomatis Nodus carbon dots (NRN-CDs) on ethanol-induced gastric ulcers in rats. Materials & methods: NRN-CDs synthesized and characterized by transmission electron microscopy, ultraviolet, fluorescence and Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy, x-ray diffraction and zeta potential analyzer. Their gastroprotective effects toward ethanol-induced gastric ulcers were evaluated in male Sprague-Dawley rats. Results: NRN-CDs showed an average diameter of 2.33 +/- 0.42 nm and a lattice spacing of 0.29 nm. Pretreatment with NRN-CDs significantly decreased the ulcer index and attenuated the severity of gastric mucosal damage, indicating that NRN-CDs exerted potent gastric protective effect. Moreover, the gastroprotection effect was related to the regulation of oxidative stress and inflammatory factors. Conclusion: NRN-CDs could be developed as a potential drug for the treatment of gastric ulcers.
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