Journal
NANOMEDICINE
Volume 16, Issue 24, Pages 2189-2206Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2021-0195
Keywords
alternating current biosusceptometry; biomedical engineering; corona protein; magnetic nanoparticles; mass spectrometry
Funding
- Sao Paulo Research Foundation (FAPESP) [2015/14923-9]
- National Council for Scientific and Technological Development (CNPq) [311074/2018-9]
- Coordination of Superior Level Staff Improvement - Brazil (CAPES)
- National Institute of Science and Technology Program (INCT - FNA/CNPq)
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The study showed that bovine serum albumin-coated magnetic nanoparticles have better biocompatibility, stability, and magnetic signal uniformity in biological media compared to citrate-coated and bare magnetic nanoparticles.
Background: We evaluated the impacts of corona protein (CP) formation on the alternating current biosusceptometry (ACB) signal intensity and in vivo circulation times of three differently coated magnetic nanoparticles (MNP): bare, citrate-coated and bovine serum albumin-coated MNPs. Methods: We employed the ACB system, gel electrophoresis and mass spectrometry analysis. Results: Higher CP formation led to a greater reduction in the in vitro ACB signal intensity and circulation time. We found fewer proteins forming the CP for the bovine serum albumin-coated MNPs, which presented the highest circulation time in vivo among the MNPs studied. Conclusion: These data showed better biocompatibility, stability and magnetic signal uniformity in biological media for bovine serum albumin-coated MNPs than for citrate-coated MNPs and bare MNPs.
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