Journal
NANOMEDICINE
Volume 16, Issue 19, Pages 1691-1712Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2021-0086
Keywords
anticancer; combination therapy; COX-2 inhibitors; nanocarriers
Ask authors/readers for more resources
COX-2 inhibitors show great potential in cancer therapy, especially when combined with nanotechnological approaches to enhance drug delivery efficiency. Celecoxib, being the most widely studied agent, demonstrates significant potential in chemoprevention and combined treatment with other drugs.
While cancer remains a significant global health problem, advances in cancer biology, deep understanding of its underlaying mechanism and identification of specific molecular targets allowed the development of new therapeutic options. Drug repurposing poses several advantages as reduced cost and better safety compared with new compounds development. COX-2 inhibitors are one of the most promising drug classes for repurposing in cancer therapy. In this review, we provide an overview of the detailed mechanism and rationale of COX-2 inhibitors as anticancer agents and we highlight the most promising research efforts on nanotechnological approaches to enhance COX-2 inhibitors delivery with special focus on celecoxib as the most widely studied agent for chemoprevention or combined with chemotherapeutic and herbal drugs for combating various cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available