4.8 Review

Aptamer functionalized nanomaterials for biomedical applications: Recent advances and new horizons

Journal

NANO TODAY
Volume 39, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2021.101177

Keywords

Nanomaterials; Aptamers; Aptasensor; Biomedical application

Funding

  1. Tabriz University of Medical Sciences, Tabriz, Iran [64820]
  2. WSU

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This review discusses the design and applications of aptamer functionalized nanomaterials (AFMs) in the biomedical field, including synthesis strategies, versatile roles of nanomaterials, and representative examples of biomedical applications. Challenges and opportunities in this emerging field are also presented.
With the advancement of functional nanomaterials and aptamer selection technologies, aptamer functio-nalized nanomaterials (AFMs) open various methods to design new sensing and imaging technologies. In this perspective, several sensitivity-enhancement methods alongside a wide range of smart nanomaterials have been incorporated to construct new AFMs to use in the biomedical field. This review first introduces the conjunction strategies for synthesizing AFMs. Then, the versatile roles of nanomaterials in advanced AFMs are discussed, including optical indicators, conducting transducer, carriers, catalysts, and other functions. Representative examples of biomedical applications are reviewed with emphasis on drug de-livery, bioimaging, and aptasensors. Finally, some challenges and opportunities in this emerging field are presented. (c) 2021 Elsevier Ltd. All rights reserved.

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