Journal
NANO LETTERS
Volume 21, Issue 19, Pages 7979-7988Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c02050
Keywords
3D covalent organic frameworks; immunogenic cell death inducers; nanotherapeutics
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Funding
- National Natural Science Foundation of China [22025106, 91545205, 91622103, 21971199]
- China Postdoctoral Science Foundation [2021M692475, 2021T140524, XJ2021037]
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A series of three-dimensional (3D) covalent organic frameworks (COFs) were designed and synthesized as inducers for immunogenic cell death (ICD) in cancer immunotherapy. These COFs exhibit outstanding ICD-inducing efficiency and one member, COF-609, showed significant therapeutic effects in a mouse model of breast cancer.
We report the design and synthesis of a series of three-dimensional (3D) covalent organic frameworks (COFs) as immunogenic cell death (ICD) inducers for cancer immunotherapy. Three triple-topic amine building blocks, inactive to inducing ICD, were used to construct three COFs, COF-607, COF-608, and COF-609, with outstanding ICD eliciting efficiency. Mechanism studies revealed that after linking these ICD inert monomers into the COF backbone, the optical properties of these COFs could be systematically tuned to achieve excellent reactive oxygen species (ROS) production performance. This combined with 3D cross-linked pores, mimicking lung structure, favor the exchange and diffusion of oxygen and ROS, leading to excellent inducing ICD efficacy. One member, COF-609, is capable of triggering abscopal and long-lasting immune memory effects in a mouse model of breast cancer with >95% mice survival after being treated with COF-609+alpha CD47 for 110 days.
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