Journal
MUCOSAL IMMUNOLOGY
Volume 14, Issue 5, Pages 1127-1132Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/s41385-021-00429-z
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Funding
- Association for Training, Education and Research in Hematology, Immunology and Transplantation
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In patients receiving allogeneic hematopoietic cell transplantation (alloHCT), higher bacterial diversity is associated with improved overall survival and disease-free survival, while high relative abundance of Candida albicans may result in lower survival rates.
Patients receiving allogeneic hematopoietic cell transplantation (alloHCT) were previously shown to display a bacterial gut dysbiosis; however, limited data are available regarding the role of fungal microbiota in these patients. We evaluated the bacterial and fungal composition of the fecal microbiota at day 0 of alloHCT. Higher bacterial diversity was associated with an improved overall survival (OS) and disease-free survival (DFS). While fungal diversity had no impact on patient outcomes, we observed that high versus low relative abundance of Candida albicans in alloHCT patients at day 0 was associated with a significantly lower OS, DFS and graft-versus-host-free, relapse-free survival (GRFS) (p = 0.0008, p = 0.0064 and p = 0.026, respectively). While these results are limited by low patient numbers and low fungal read counts in some samples, they suggest a potentially important role for C albicans in alloHCT.
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