Journal
MONATSHEFTE FUR CHEMIE
Volume 152, Issue 10, Pages 1127-1171Publisher
SPRINGER WIEN
DOI: 10.1007/s00706-021-02834-3
Keywords
Buchwald-Hartwig reaction; Carbon-nitrogen bond; Palladium; Natural products; Heterocycles
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The carbon-nitrogen cross-coupling reaction is crucial in organic synthesis, with arylamines being key frameworks in natural products and pharmaceuticals. Buchwald and Hartwig have made significant contributions by introducing a variety of ligands for this important reaction. Recent advances show that the Buchwald-Hartwig reaction has extensive applications in organic synthesis and total synthesis of natural products.
Carbon-nitrogen cross-coupling reaction is an imperative and vital conversion in organic synthesis since one of its products, arylamines, are key frameworks in several natural products, pharmaceuticals, and other biologically active compounds. For the development of such important C-N coupling reaction, Buchwald and Hartwig made noteworthy contributions by presenting a plethora of ligands in addition to the conventional Pd and Cu catalysts. In this review, we try to update our previous review, covering the recent progresses in applications of Buchwald-Hartwig reaction in organic reactions, in the synthesis of heterocyclic compounds and total synthesis of natural products. This review covers this important advancement from 2018 till date. [GRAPHICS]
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