Journal
MOLECULES
Volume 26, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/molecules26133839
Keywords
antimicrobial peptide dendrimers; quorum-sensing inhibitors; MvfR; PqsR; anti-infection dressing; cell therapy; biological bandage; burn wound
Funding
- SwissTransmed CRUS grant [14/2013]
- Swiss National Science Foundation [200020_159941]
- Swiss National Science Foundation (SNF) [200020_159941] Funding Source: Swiss National Science Foundation (SNF)
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In this article, a novel cell therapy formulation is developed to resist infections and inhibit the virulence pathways of pathogenic bacteria by incorporating antimicrobial peptide dendrimers and anti-quorum sensing compounds. The formulation includes live progenitor cells, exhibiting bactericidal and anti-virulence properties without compromising cell viability.
Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for delivery of cells could be potential substrates to support bacterial growth and subsequent lysis of the collagen leading to a cell therapy loss. In this article, we report the development of a new generation of cell therapy formulations with the capacity to resist infections through the bactericidal effect of antimicrobial peptide dendrimers and the anti-virulence effect of anti-quorum sensing MvfR (PqsR) system compounds, which are incorporated into their formulation. Anti-quorum sensing compounds limit the pathogenicity and antibiotic tolerance of pathogenic bacteria involved in the burn wound infections, by inhibiting their virulence pathways. For the first time, we report a biological cell therapy dressing incorporating live progenitor cells, antimicrobial peptide dendrimers, and anti-MvfR compounds, which exhibit bactericidal and anti-virulence properties without compromising the viability of the progenitor cells.
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