4.6 Article

Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria

Journal

MOLECULES
Volume 26, Issue 16, Pages -

Publisher

MDPI
DOI: 10.3390/molecules26165083

Keywords

pyrazole; aniline; Staphylococcus aureus; Enterococcus faecium; MRSA; Enterococcus faecalis; VRE

Funding

  1. Arkansas INBRE [P20 GM103429]
  2. Kays Foundation

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This study reports the design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives, most of which are potent growth inhibitors of planktonic Gram-positive bacteria. Several lead compounds were identified to be bactericidal and effective against MRSA persisters, as well as S. aureus biofilms.
Enterococci and methicillin-resistant S. aureus (MRSA) are among the menacing bacterial pathogens. Novel antibiotics are urgently needed to tackle these antibiotic-resistant bacterial infections. This article reports the design, synthesis, and antimicrobial studies of 30 novel pyrazole derivatives. Most of the synthesized compounds are potent growth inhibitors of planktonic Gram-positive bacteria with minimum inhibitory concertation (MIC) values as low as 0.25 mu g/mL. Further studies led to the discovery of several lead compounds, which are bactericidal and potent against MRSA persisters. Compounds 11, 28, and 29 are potent against S. aureus biofilms with minimum biofilm eradication concentration (MBEC) values as low as 1 mu g/mL.

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