Journal
MOLECULES
Volume 26, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/molecules26133973
Keywords
gold(III); 2,2 '-bipyridine-3,3 '-dicarboxylic acid; anti-cancer activity; dithiocarbamates; apoptosis
Funding
- Deanship of Scientific Research at King Saud University [RG-1441-496]
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Three novel gold(III) complexes were synthesized and showed high cytotoxicity against various cancer cells. One of the complexes was found to induce cell death through apoptosis pathway.
Three novel gold(III) complexes (1-3) of general composition [Au(Bipydc)(S2CNR2)]Cl-2 (Bipydc = 2,2 '-bipyridine-3,3 '-dicarboxylic acid and R = methyl for dimethyldithiocarbamate (DMDTC), ethyl for diethyldithiocarbamate (DEDTC), and benzyl for dibenzyldithiocarbamate (DBDTC)) have been synthesized and characterized by elemental analysis, FTIR and NMR spectroscopic techniques. The spectral results confirmed the presence of both the Bipydc and dithiocarbamate ligands in the complexes. The in vitro cytotoxic studies demonstrated that compounds 1-3 were highly cytotoxic to A549, HeLa, MDA-231, and MCF-7 cancer cells with activities much higher (about 25-fold) than cisplatin. In order to know the possible mode of cell death complex 2, [Au(Bipydc)(DEDTC)]Cl-2 was further tested for induction of apoptosis towards the MCF-7 cells. The results indicated that complex 2 induces cell death through apoptosis.
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