Thiazole Ring-A Biologically Active Scaffold

Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal, antimalarial, anticancer, antiallergic, antihypertensive, anti-inflammatory, and antipsychotic. Indeed, the thiazole scaffold is contained in more than 18 FDA-approved drugs as well as in numerous experimental drugs. Objective: To summarize recent literature on the biological activities of thiazole ring-containing compounds Methods: A literature survey regarding the topics from the year 2015 up to now was carried out. Older publications were not included, since they were previously analyzed in available peer reviews. Results: Nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.

Automated summary

Thiazole is a valuable pharmacophore nucleus with a wide range of biological activities, including antioxidant, analgesic, antimicrobial, antihypertensive, anti-inflammatory, and antipsychotic properties. Recent literature review identified and critically analyzed nearly 124 research articles on the synthesis and biological activities of thiazoles derivatives in the past 5 years.