Journal
MOLECULES
Volume 26, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/molecules26113164
Keywords
Haliclona densaspicula; densazalin; 1; 3-alkylpyridine; cytotoxic alkaloid
Funding
- Ministry of Oceans and Fisheries, Korea [20190518]
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Densazalin, a polycyclic alkaloid isolated from a marine sponge collected in Korea, possesses a unique structure and exhibits cytotoxic activity against two human tumor cell lines.
Densazalin, a polycyclic alkaloid, was isolated from the marine sponge Haliclona densaspicula collected in Korea. The complete structure of the compound was determined by spectroscopic methods, including 1D and 2D nuclear magnetic resonance techniques, high-resolution mass spectrometry, and comparison of the calculated and measured electronic circular dichroism spectra. Densazalin possesses a unique 5,11-diazatricyclo[7.3.1.0(2,7)]tridecan-2,4,6-triene moiety, which is connected by two linear carbon chains. This compound was derived from the biogenetic precursor bis-1,3-dialkylpyridnium. Densazalin exhibited cytotoxic activity on two human tumor cell lines (AGS and HepG2) in the Cell Counting Kit-8 (CCK-8) bioassay, with IC50 values ranging from 15.5 to 18.4 mu M.
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