Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives

Due to their structural similarity with natural alpha-amino acids, alpha-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their absolute configuration, the synthesis of alpha-aminophosphonates bearing tetrasubstituted carbons in an asymmetric fashion has grown in interest in the past few decades. In the following lines, the existing literatures for the synthesis of optically active tetrasubstituted alpha-aminophosphonates are summarized, comprising diastereoselective and enantioselective approaches.

Automated summary

Alpha-aminophosphonic acid derivatives are biologically active molecules due to their structural similarity to natural alpha-amino acids. The synthesis of alpha-aminophosphonates with tetrasubstituted carbons in an asymmetric manner has gained interest in recent decades, given the importance of tetrasubstituted carbons in nature and medicine and the biological activity dependence on absolute configuration of chiral molecules. Existing literature on the synthesis of optically active tetrasubstituted alpha-aminophosphonates, involving diastereoselective and enantioselective approaches, is summarized.